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Effect of Heparin on Hemagglutinin of Herpes Simplex Virus Type 1
Author(s) -
Noda Masahiro,
Inaba Yuji,
Seno Masato,
Kanamoto Yasuo,
Tokumoto Shizuyo
Publication year - 1993
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1993.tb01733.x
Subject(s) - heparin , herpes simplex virus , hemagglutinin (influenza) , hemagglutination , virus , biology , virology , simplexvirus , microbiology and biotechnology , herpesviridae , biochemistry , viral disease
Heparin inhibited the hemagglutinin activity of herpes simplex virus (HSV) type 1. The minimal inhibitory concentration of heparin required to inhibit 8 hemagglutination (HA) U of HSV ranged from 0.005 to 0.01 U/ml. Mouse erythrocytes failed to combine with the HA inhibitory factor of heparin. On the other hand, mouse erythrocytes treated with heparinase had greatly reduced agglutinability by HSV. Virus‐heparin complex formation was observed by sedimenting heparin with the virus particles.