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Comparison of Virulence between Seoul Virus Strain SR‐11 and Hantaan Virus Strain 76–118 of Hantaviruses in Newborn Mice
Author(s) -
Yoo Yung Choon,
Yoshimatsu Kumiko,
Yoshida Ryu,
Tamura Mizuho,
Azuma Ichiro,
Arikawa Jiro
Publication year - 1993
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1993.tb01677.x
Subject(s) - virulence , hantaan virus , hantavirus , virology , biology , strain (injury) , virus , microbiology and biotechnology , bunyaviridae , gene , genetics , anatomy
Virulence of hantavirus strain of SR‐11 Seoul virus and Hantaan 76–118 (HTN) of Hantaan virus were compared. Infections of both strains were lethal in newborn mice. However, inoculum required to cause lethal infection was about 4,000 times higher for strain HTN (1.65 × 10 3 PFU/mouse/LD 50 ) than for strain SR‐11 (0.36 PFU). Thus, both strains were considered pathogenic to newborn mice but they possessed different levels of virulence. The assay system used for these strains in newborn mice proved to be useful in the study of hantavirus vilurence. Growth curves of the two strains in CV‐7 cell cultures were compared. Strain SR‐11 was shown to have higher activity of virus replication and virus release into the culture fluids than strain HTN. The possibility of a relationship between replication activity and high levels of virulence in mice was suggested.