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Augmentation of Bovine Leukemia Virus (BLV)‐Specific Lymphocyte Proliferation Responses in Ruminants by Inoculation with BLV env ‐Recombinant Vaccinia Virus: Their Role in the Suppression of BLV Replication
Author(s) -
Ohishi Kazue,
Suzuki Hidemi,
Yasutomi Yasuhiro,
Onuma Misao,
Okada Kosuke,
Numakunai Shigeru,
Ohshima Kanichi,
Ikawa Yoji,
Sugimoto Masanobu
Publication year - 1992
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1992.tb02133.x
Subject(s) - biology , virology , bovine leukemia virus , vaccinia , virus , immune system , lymphocyte , recombinant dna , cellular immunity , immunity , viral replication , immunology , biochemistry , gene
Lymphocyte proliferation responses were investigated in sheep and cattle, in which the replication of bovine leukemia virus (BLV) had been known to be suppressed by inoculation with recombinant vaccinia virus (rVV) expressing BLV envelope glycoprotein (gp60). Enhanced lymphocyte proliferation responses were observed in animals inoculated with rVV, regardless of whether they were naive or BLV carriers. These responses were roughly inversely correlated to the growth of BLV in the peripheral blood leukocytes. In contrast, there was no apparent correlation between humoral immune response and BLV growth. Based on these results, it was suggested that rVV rendered its suppressive effect of BLV replication primarily via augmentation of cell‐mediated immunity.