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IgG Subclass Alterations in Adult Asthma
Author(s) -
Outschoorn Ingrid M.,
Natta Clayton L.
Publication year - 1992
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1992.tb02101.x
Subject(s) - subclass , biology , asthma , immunology , antibody
Immunoglobulin levels were measured in serum samples of 12 black adult non‐smoking asthmatic patients, 11 females and 1 male, and compared with 15 age‐, sex‐matched normal controls. Their total IgG, IgA and IgM levels were within the normal range. However, on quantitation of subclasses, IgG1 levels were significantly above normal, while IgG2 and IgG3 levels were significantly lower than those of controls. No significant differences were found between the two groups when IgG4 levels were compared. These studies as well as those of others suggest that immunoglobulin administration, particularly of individual subclasses, might prove to be a beneficial addition in the management of this condition.