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Effects of Gamma‐Interferon and FK506 on Resting B Cell Proliferation of New Zealand Black/White F 1 Mice
Author(s) -
Minoda Masahide,
Ohno Motoki,
Tomioka Yoshiki,
Hamada Kinya,
Yamazoe Yasushi,
Higashikawa Mitsuhiro,
Sugishima Hitoshi,
Higashitani Sumihiko,
Funauchi Masanori,
Horiuchi Atsushi
Publication year - 1992
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1992.tb02090.x
Subject(s) - biology , white (mutation) , interferon gamma , cell growth , immunology , genetics , cytokine , gene
We examined the effects of gamma‐interferon (γ‐IFN) and the new immunosuppressant FK506 on resting B cell proliferation of New Zealand black/white F 1 hybrid (B/W F 1 ) mice, an animal model of human systemic lupus erythematosus (SLE). γ‐IFN and FK506 inhibited in a dose‐dependent manner both B cell proliferation and autoantibody production of resting B cells respectively. There was a synergistic interaction between γ‐IFN and FK506 in their inhibition and they did not exhibit cell cytotoxicity. This in vitro synergism of γ‐IFN and FK506 may have clinical application in that low doses of γ‐IFN and FK506 combinations may be effective to correct polyclonal B cell activation of patients with SLE.