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Latent Infection of SCID Mice with Herpes Simplex Virus 1 and Lethal Cutaneous Lesions in Pregnancy
Author(s) -
Moriyama Kosei,
Mohri Shirou,
Watanabe Takeshi,
Mori Ryoichi
Publication year - 1992
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1992.tb02086.x
Subject(s) - herpes simplex virus , biology , lytic cycle , virology , virus , herpesviridae , viral replication , latency (audio) , pregnancy , virus latency , immunology , viral disease , genetics , electrical engineering , engineering
Some SCID mice survived primary infection with herpes simplex virus 1 without the development of peripheral lesions but established coculture‐positive ganglionic latency when a low dose of a wild‐type strain was inoculated intracutaneously. The latency was also evidenced by the development of the fatal zosteriform skin lesions and the isolation of the virus during pregnancy. We consider that the viral entry into neurons without successive replication, rather than the arrest of the lytic infection within the cells, is an important mechanism in the establishment of latency.