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Sequence Comparison of the Capsid Region of Hepatitis E Viruses Isolated from Myanmar and China
Author(s) -
Aye Thein Thein,
Uchida Toshikazu,
Ma Xuezhung,
Iida Fusae,
Shikata Toshio,
Zhuang Hui,
Win Khin Maung
Publication year - 1992
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1992.tb02061.x
Subject(s) - biology , virology , capsid , nucleic acid sequence , strain (injury) , peptide sequence , sequence analysis , genetics , china , sequence (biology) , gene , virus , geography , archaeology , anatomy
Hepatitis E viruses (HEVs) were isolated during epidemics, one from Myanmar (formerly called Burma) and one from China and were partially sequenced. Another HEV Myanmar strain from sporadic hepatitis was previously sequenced by us. A cDNA sequence comparison was performed among them in the 3′‐terminal region, approximately 750‐base long. This region contained at least two immunological epitopes and was considered to correspond to the structural protein. The nucleotide sequence identity was 97.2% between the two Myanmar strains and 93.3 and 92.5% between the two Myanmar and the China strain. The deduced amino acid sequence identity ranged from 98.4 to 100.0% among the three strains. Thus this segment was well conserved on the amino acid level among the different strains isolated from these two Asian countries, although the China strain diverged more from the Myanmar strains on the nucleotide sequence level. This data may provide important information for the development of a vaccine and for identification of the virological link between different geographical locations.