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Conspicuous Ingestion of Staphylococcus aureus Organisms by Murine Fibroblasts In Vitro
Author(s) -
Usui Akemi,
Murai Miyo,
Seki Keiko,
Sakurada Junji,
Masuda Shogo
Publication year - 1992
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1992.tb02054.x
Subject(s) - staphylococcus aureus , biology , microbiology and biotechnology , in vitro , ingestion , fibroblast , micrococcaceae , staphylococcal infections , staphylococcus epidermidis , staphylococcus saprophyticus , bacteria , genetics , biochemistry
A conspicuous adhesion of Staphylococcus aureus organisms to murine cutaneous fibroblasts and NIH/3T3 cells cultured in vitro and subsequent ingestion of S. aureus organisms by these fibroblasts are described. In the present experimental system, only fibroblasts‐adhering S. aureus organisms were efficiently ingested by fibroblasts unlike S. epidermidis and S. saprophytics . These findings might suggest a correlation between the pathogenesis of S. aureus and its intracellular localization in non‐professional phagocytes such as fibroblasts in a special reference to its higher pathogenicity than those of coagulase negative counterparts.