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Antiviral Activity of a Bile Pigment, Biliverdin, against Human Herpesvirus 6 (HHV‐6) In Vitro
Author(s) -
Nakagami Tatsuyoshi,
Taji Shiro,
Takahashi Michiaki,
Yamanishi Koichi
Publication year - 1992
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1992.tb02037.x
Subject(s) - biology , virus , herpes simplex virus , in vitro , viral replication , virology , human herpesvirus 6 , virus quantification , herpesviridae , microbiology and biotechnology , biochemistry , viral disease
Biliverdin (BV), a bile pigment, was examined for its antiviral activity against human herpesvirus‐6 (HHV‐6) in vitro . BV (10 μg/ml) markedly inhibited HHV‐6 replication in MT‐4 cells when the cells were treated during a virus adsorption period. Its antiviral effect was weakened when cells were treated after adsorption. Treatment of cells with BV (40 μg/ml) 3 hr after virus infection had no inhibitory effect on virus replication. Virus replication was also significantly inhibited by treatment of MT‐4 cells with BV (10 μg/ml) before infection, while the virions were not inactivated by BV (20 μg/ml). Bilirubin and urobilin, metabolic derivatives of BV, showed slight inhibitory effects on virus replication in the cells. On the other hand, BV had no potent inhibitory activity in the replication of herpes simplex virus‐1 or human cytomegalovirus. These observations suggest that BV could interact with MT‐4 cells to inhibit an early stage of HHV‐6 infection in a virus‐specific manner.