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Interactions between Immune‐Stimulating Complexes (ISCOMs) and Peritoneal Mononuclear Leucocytes
Author(s) -
Watson Dennis L.,
Watson Nikki A.,
Fossum Caroline,
Lovgren Karin,
Morein Bror
Publication year - 1992
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1992.tb01657.x
Subject(s) - biology , immune system , micelle , peripheral blood mononuclear cell , antigen , internalization , glycoprotein , microbiology and biotechnology , virology , immunology , cell , chemistry , biochemistry , in vitro , aqueous solution
Studies were undertaken in mice using immune‐stimulating complexes (ISCOMs) or micelles prepared from envelope glycoproteins of human influenza virus (PR8) and matrix (i.e., ISCOM skeleton without incorporated antigen). Electron microscopic studies showed that ISCOMs, in contrast to micelles, have a remarkable affinity for cell membranes and seem to rapidly promote their own internalization by cells to which they adhere. PR8 ISCOMs, but not matrix nor micelles, significantly increased the expression of membrane Ia by peritoneal mononuclear leucocytes 24 hr after intraperitoneal immunization.