Premium
Accumulation of Ascites and Increase in Skin Vascular Permeability Observed by Injection of Adsorbed Diphtheria‐Purified Pertussis‐Tetanus Combined Vaccine in Guinea Pigs
Author(s) -
Goto Norihisa,
Kato Hiroshi
Publication year - 1991
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1991.tb01635.x
Subject(s) - tetanus , diphtheria , vascular permeability , ascites , corynebacterium diphtheriae , intraperitoneal injection , immunology , biology , chemistry , microbiology and biotechnology , medicine , pharmacology , vaccination , endocrinology
Intraperitoneal injection of adsorbed diphtheria‐purified pertussis‐tetanus combined vaccine (DPPT) often causes an ascites‐accumulating (A‐A) reaction in guinea pigs. Those vaccines which caused A‐A reaction increase the vascular permeability (VP) of the skin tissue at the intracutaneous injection sites. A total of 23 lots of DPPT were assayed for A‐A and VP‐increasing activities. A positive correlation between the volume of ascites accumulated and the intensity of VP was significant. Other kinds of aluminum‐adsorbed (Al‐Ad) vaccines such as Al‐Ad tetanus and Al‐Ad diphtheria‐tetanus combined and Al‐Ad hepatitis B vaccines induced little or no A‐A reaction. These results were discussed from the viewpoint of quality control in the process of the production of DPPT.