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Novel Cell Surface Antigens Expressed on Mouse Alveolar Macrophages
Author(s) -
Yoshikawa Kazuhiro,
Suzuki Yasumoto,
Kawai Makoto,
Fukada Masako,
Yokochi Takashi
Publication year - 1991
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1991.tb01613.x
Subject(s) - antigen , monoclonal antibody , macrophage , biology , antibody , bone marrow , pathology , peritoneal cavity , microbiology and biotechnology , surface immunoglobulin , immunology , alveolar macrophage , b cell , medicine , anatomy , biochemistry , in vitro
Two new cell surface antigens expressed on mouse alveolar macrophages were defined by rat monoclonal antibodies. One marker, AVM‐1, was detected on mouse alveolar macrophages, but it was undetectable on resident peritoneal cells, thioglycollate medium‐induced peritoneal cells, and splenic macrophages. Splenic lymphocytes, thymocytes and bone marrow cells were also AVM‐1 negative. Anti‐AVM‐1 monoclonal antibody immunoprecipitated a single polypeptide with a molecular weight of 200,000. Of particular interest was the finding that the anti‐AVM‐1 antibody could inhibit the formation of EA and EAC rosette on macrophage line cells. A second antigen (AVM‐2) was also present on alveolar macrophages. and its molecular weight was 38,000.