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Bacterial Translocation from the Gastrointestinal Tract in Various Mouse Models for Human Diabetes
Author(s) -
Ohsugi Takeo,
Maejima Kazuyoshi,
Urano Toru
Publication year - 1991
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1991.tb01611.x
Subject(s) - streptozotocin , diabetes mellitus , chromosomal translocation , gastrointestinal tract , alloxan , nod , medicine , endocrinology , nod mice , biology , biochemistry , gene
Bacterial translocation from the gastrointestinal (GI) tract to other internal organs was examined in multiple low‐dose streptozotocin‐injected (M‐STZ), single large‐dose streptozotocin‐injected (S‐STZ), alloxan‐injected (Alloxan), and non‐obese diabetic (NOD) mice. The incidence of bacterial translocation from the GI tract to the tested organs among diabetic mice was in the order of M‐STZ mice>S‐STZ mice>NOD, Alloxan, and control mice. The injections of insulin to M‐STZ mice did not decrease the incidence of translocation. These results suggest that bacterial translocation from the GI tract in diabetic mice is not induced by diabetes.