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Stimulation of Phagocytic Processes and Antibody‐Dependent Cellular Cytotoxicity of Human Neutrophils by Cefmetazole
Author(s) -
Rodriguez Ana Beatriz,
Barriga Carmen,
Fuente Monica
Publication year - 1991
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1991.tb01585.x
Subject(s) - cefmetazole , chemotaxis , antibody dependent cell mediated cytotoxicity , cytotoxicity , microbiology and biotechnology , candida albicans , biology , degranulation , ingestion , in vitro , antibody , stimulation , immunology , antibiotics , cephalosporin , biochemistry , endocrinology , receptor
Interactions between antimicrobial agents and phagocytic cells, especially neutrophils, have a potential role in the treatment of infections. The in vitro effects of cefmetazole, a novel β‐lactarn antibiotic, at a therapeutic concentration reached in plasma (50 μg/ml) on phagocytic and cytotoxic functions of human neutrophils have been studied. In human neutrophils, adherence capacity to nylon fiber and to substrate, chemotaxis, attachment to and ingestion of Candida albicans (with serum, with decomplemented serum and without serum), ingestion of inert particles (latex beads), candidicidal activity and superoxide anion production were all stimulated by cefmetazole. Cefmetazole at this dose was a chemotactic agent for neutrophils. Antibody‐dependent cellular cytotoxicity (ADCC) was also increased by this antimicrobial agent.