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Characterization of Antibody Response to Pseudomonas aeruginosa in Patients with Wound Infections
Author(s) -
Trafny Elzbieta Anna,
Grzybowski Jacek,
Patzer Jan,
Popiel Danuta,
WrembelWargocka Jolanta,
Dzierzanowska Danuta,
ZawistowskaMarciniak Irena,
Kobus Kazimierz
Publication year - 1991
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1991.tb01574.x
Subject(s) - avidity , pseudomonas aeruginosa , antibody , pseudomonas exotoxin , microbiology and biotechnology , biology , immunology , exotoxin , lipopolysaccharide , bacteria , toxin , genetics
ELISA was used to measure the amount and avidity of IgG antibodies to exotoxin A (ExA) and 7 Fisher's immunotypes of lipopolysaccharide (LPS) in the sera of 13 patients with mild or moderate Pseudomonas aeruginosa infections. Changes in the specificity of tested sera during the course of infection were demonstrated. A statistically significant increase was seen in the amount and avidity of the antibodies to ExA in a majority of the sera, and an increase was seen in amount of antibodies to LPS immunotype 4 in the sera of patients with moderate infections.