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Preventive Effects of a Chinese Herb Medicine (Sho‐saiko‐to) against Lethality after Recombinant Human Tumor Necrosis Factor Administration in Mice
Author(s) -
Sakaguchi Shuhei,
Tutumi Eiji,
Yokota Katushi,
Furusawa Shinobu,
Sasaki Kenichi,
Takayanagi Yoshio
Publication year - 1991
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1991.tb01569.x
Subject(s) - tumor necrosis factor alpha , lethality , medicine , herb , pharmacology , recombinant dna , necrosis , tumor necrosis factor α , traditional chinese medicine , immunology , traditional medicine , medicinal herbs , biology , pathology , toxicology , biochemistry , alternative medicine , gene
We observed the effects of a Chinese herb medicine Sho‐saiko‐to on the lethal and antitumor activities of recombinant human tumor necrosis factor (rhTNF) administered in mice. Sho‐saiko‐to was noted to protect the rhTNF‐induced lethality in galactosamine‐hypersensitized mice, and also Sho‐saiko‐to pretreated mice was protected against the decrease of rectal temperature after rhTNF administration. On the other hand, there was a remarkable enhancement of antitumor activity of rhTNF by Sho‐saiko‐to pretreatment. These results suggest that Sho‐saiko‐to drug may protect mice from severe shock syndrome induced by rhTNF.