Premium
Susceptibility of Newly Established Mouse Strain MPS to Mycoplasma pneumoniae Infection
Author(s) -
Sasaki Yuko,
Ogura Atuo,
Nakayama Kazue,
Noguchi Yoko,
Matsuno Kumiko,
Saito Manabu
Publication year - 1991
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1991.tb01553.x
Subject(s) - mycoplasma pneumoniae , mycoplasmataceae , microbiology and biotechnology , biology , strain (injury) , mollicutes , virology , mycoplasma , pneumonia , medicine , anatomy
A newly established mouse strain, MPS, which is more sensitive to Mycoplasma pulmonis than ICR, ddY and other mouse strains was examined for its susceptibility to Mycoplasma pneumoniae. In experimental infections with M. pneumoniae , it was observed that M. pneumoniae attached to tracheas of MPS mice, and M. pneumoniae cells were isolated from tracheas and lungs of MPS mice even after four weeks of infection, while no mycoplasmas were isolated from ICR and ddY mice after one week of infection. Specific antibodies against M. pneumoniae were also observed by the Western blotting in the sera of MPS mice infected with M. pneumoniae. Although any lung lesion could not be observed in this work, this newly established mouse strain MPS may be useful for experiments of M. pneumoniae infection, especially for the analysis of strain differences in susceptibility to M. pneumoniae infection.