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Lack of Response of Murine Peritoneal Macrophages to in vitro Activation by Muramyl Dipeptide (MDP)
Author(s) -
Nagao Shigeki,
Akagawa Kiyoko S.,
Yamada Kazuo,
Yagawa Katsuro,
Tokunaga Tohru,
Kotani Shozo
Publication year - 1990
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1990.tb01013.x
Subject(s) - muramyl dipeptide , in vitro , biology , microbiology and biotechnology , dipeptide , macrophage , immunology , inflammatory response , inflammation , biochemistry , peptide
Peritoneal exudate macrophages from mice, rats, and guinea pigs were assessed using six different parameters of macrophage activation to determine whether the cells were stimulated under similar experimental conditions. Peritoneal exudate macrophages from mice, irrespective of strain, were far less responsive to a variety of in vitro stimulatory effects of N ‐acetylmuramyl‐ L ‐alanyl‐D‐isoglutamine than those from rats or guinea pigs, while no significant differences were noted with the reactivity to stimulation by endotoxic lipopolysaccharide. We conclude that macrophage activation by MDP in vitro is species dependent.