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Specificity of Salmonella Porin as an Eliciting Antigen for Cell‐Mediated Immunity (CMI) Reaction in Murine Salmonellosis
Author(s) -
Matsui Katsuhiko,
Arai Toshihiko
Publication year - 1989
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1989.tb03165.x
Subject(s) - porin , salmonella , salmonella enteritidis , microbiology and biotechnology , biology , enterobacteriaceae , antigen , immunity , escherichia coli , serotype , immunology , bacterial outer membrane , immune system , bacteria , gene , biochemistry , genetics
The specificities of Salmonella porin on elicitations of delayed‐type hypersensitivity (DTH) reaction and interleukin‐2 (IL‐2) production in BALB/c mice immunized with Salmonella typhimurium were examined. Only porin from S. typhimurium was capable of eliciting significant levels of DTH and IL‐2 production in S. typhimurium‐immunized mice, whereas no significant DTH and IL‐2 production were induced by porin from Salmonella enteritidis or Escherichia coli . Our observations suggested that Salmonella porin was a serovar‐specific antigen for the elicitation of cell‐mediated immunity (CMI) in salmonellosis.