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Immunopathology of Chronic Progressive Hepatitis in Nude Mice Infected with Low‐Virulent Mouse Hepatitis Virus
Author(s) -
Midoro Katsuo,
Nakanaga Kazue,
Kyuwa Shigeru,
Fujiwara Kôsaku
Publication year - 1989
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1989.tb02017.x
Subject(s) - virology , virus , virulence , mouse hepatitis virus , antibody , spleen , biology , immunology , hepatitis b virus , hepatitis , medicine , pathology , infectious disease (medical specialty) , biochemistry , disease , covid-19 , gene
Progressive hepatitis in athymic nude ( nu/nu ) mice due to a low‐virulent mouse hepatitis virus, MHV‐2 cc, was examined for involvement of immunocytes and serum antibodies. At 3 to 6 weeks postinoculation (p.i.) a considerable number of Mac 1‐ and asialo GM1‐positive cells were accumulated in the affected liver and spleen. There were also some Thy‐1‐positive cells. Later than 2 weeks p.i., serum IgG and IgM antibodies were detected in parallel with virus‐neutralizing activity, while the IgG levels were lower than those of infected euthymic ( nu / +) littermates. By transfer of the infected nu/nu mouse serum, the recipient euthymic mice acquired resistance to lethal challenge infection with a virulent virus, MHV‐2.