Premium
Protective Role of Human Antibody to the Fusion Protein of Measles Virus
Author(s) -
Sato Takeshi A.,
Kohama Tomoaki,
Sugiura Akira
Publication year - 1989
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1989.tb02010.x
Subject(s) - measles virus , virology , measles , antibody , biology , virus , hemolysis , encephalitis , neutralizing antibody , immunology , vaccination
Absorption of a pooled human gamma globulin preparation with acetone‐treated measles virus‐infected cells removed all antibodies to measles virus antigens except a portion of the antibody to the fusion (F) protein. The residual anti‐F antibody had hemolysis‐inhibiting and virus‐neutralizing activities, inhibited spread of infection through cell fusion, and was effective in protection of passively immunized mice from fatal measles encephalitis, providing evidence for the protective role of human antibody to the F protein of measles virus.