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Antigenic Variation among Sendai Virus Strains Detected by Monoclonal Antibodies
Author(s) -
Yamaguchi Ryoji,
Iwai Hiroshi,
Ueda Katsumoto
Publication year - 1989
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1989.tb01506.x
Subject(s) - sendai virus , monoclonal antibody , biology , virology , virus , antibody , antigen , strain (injury) , monoclonal , antigenic variation , immunology , anatomy
Abstract Thirteen strains of Sendai virus isolated from various sources in the 1950′s and after 1976 were compared for their reactivities with monoclonal antibodies prepared against the prototype strain MN of Sendai virus. Results revealed that while the 5 strains isolated in the 1950′s reacted with all the monoclonal antibodies as the prototype strain did, the 2 strains isolated in 1976 and 1978 did not react with an F‐specific monoclonal antibody, and the other 6 strains isolated after 1978 lacked reactivity with an HN‐specific monoclonal antibody.