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Isolation of a Coxiella burnetii Strain That Has Low Virulence for Mice from a Patient with Acute Q Fever
Author(s) -
Oda Hiroshi,
Yoshiie Kiyotaka
Publication year - 1989
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1989.tb00984.x
Subject(s) - coxiella burnetii , q fever , virulence , biology , strain (injury) , virology , rickettsiales , titer , isolation (microbiology) , microbiology and biotechnology , antibody titer , antibody , cyclophosphamide , immunology , bacteria , virus , gene , chemotherapy , biochemistry , genetics , anatomy
Coxiella burnetii was isolated from a patient with Q fever. It could not be determined whether this was an imported case or an indigenous one. Identification of the isolate was made by electron microscopic morphology and the indirect fluorescent antibody test with convalescent‐phase serum from a Q fever patient having a known titer of antibody to C. burnetii . The isolated strain, named TK‐1, caused no symptoms in ddY and BALB/c mice except when the mice were treated with cyclophosphamide.