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The Caries Inhibitory Effects of GOS‐Sugar in vitro and in Rat Experiments
Author(s) -
Ooshima Takashi,
Fujiwara Taku,
Takei Tsutomu,
Izumitani Akira,
Sobue Shizuo,
Hamada Shigeyuki
Publication year - 1988
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1988.tb01474.x
Subject(s) - biology , in vitro , sugar , inhibitory postsynaptic potential , biochemistry , neuroscience
The caries inhibitory activity of GOS‐sugar (panose‐ and maltose‐rich sugar mixture) was examined and compared with that of sucrose, maltose, or glucose in in vitro and in vivo experiments. Streptococcus mutans MT8148R (serotype c ) and Streptococcus sobrinus 6715 ( g ) did ferment GOS‐sugar and produce acid in a similar way as with maltose and glucose. However, GOS‐sugar could not be a substrate for the glucosyltransferases (GTases) of these mutans streptococci to synthesize the water‐insoluble glucan. Also, it significantly inhibited not only the synthesis of water‐insoluble glucan from sucrose by the crude GTases but also the sucrose‐dependent adherence of these cells to a glass surface. In particular, adherence of growing cells of 6715 was markedly inhibited by the presence of GOS‐sugar. GOS‐sugar was found to induce significant but minimal dental caries in SPF rats infected with either MT8148R or 6715. Furthermore, the replacement of half of the dietary sucrose content with GOS‐sugar resulted in a significant reduction of caries development in rats infected with strain 6715.