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Effect of Recombinant Murine Interferon‐Beta on the Replication of Murine Cytomegalovirus
Author(s) -
Nakamura Kazuo,
Eizuru Yoshito,
Minamishima Yoichi
Publication year - 1988
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1988.tb01454.x
Subject(s) - vesicular stomatitis virus , biology , virology , recombinant dna , cytomegalovirus , rhabdoviridae , interferon , embryo , virus , viral replication , vesicular stomatitis , in vitro , intracellular , vesicular stomatitis indiana virus , microbiology and biotechnology , beta (programming language) , herpesviridae , viral disease , biochemistry , computer science , gene , programming language
Pretreatment of mouse embryo fibroblasts (MEF) with recombinant murine interferon‐ β (rMuIFN‐ β ) induced a high level of intracellular 2′,5′‐oligoadenylate (2–5A) synthetase activity. However, murine cytomegalovirus (MCMV) replicated under such condition, indicating that MCMV is relatively insensitive in vitro to rMuIFN‐ β. Thus, there was a dissociation of 2–5A synthetase activity and antiviral activity against MCMV. In contrast to MCMV, the two parameters were closely associated in the case of vesicular stomatitis virus (VSV).