Premium
Effect of Temperature on Antibacterial Activity of Lidocaine to Staphylococcus aureus and Pseudomonas aeruginosa
Author(s) -
Taki Yoshiharu,
Seki Keiko,
Ikigai Hajime,
Nishihara Shoko,
Ueno Hiroshi,
Murota Kagehisa,
Masuda Shogo
Publication year - 1988
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1988.tb01402.x
Subject(s) - staphylococcus aureus , pseudomonas aeruginosa , microbiology and biotechnology , biology , antibacterial activity , bacteria , genetics
The effect of temperature on the antibacterial activity of lidocaine to Staphylococcus aureus and Pseudomonas aeruginosa was investigated in vitro. At 10 C at which S. aureus organisms do not grow and might be metabolically inactive, the antibacterial activity of lidocaine to S. aureus was not observed in a concentration of 1%, which was quite antibacterial to S. aureus at 37 C. On the other hand, at 40 C a conspicuously increased antibacterial activity to S. aureus of lidocaine was observed in a concentration of 0.25% which was not antibacterial to S. aureus organisms at 37 C. Similar results were obtained when P. aeruginosa organisms were examined in place of S. aureus , although P. aeruginosa was found to be less susceptible to lidocaine than S. aureus. The clinical significance of the thermal effect on the antibacterial activity of lidocaine was discussed in brief.