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Biological Activities of Lipid A from Vibrio parahaemolyticus : Stimulation of Murine Peritoneal Macrophages
Author(s) -
Bandekar Jayant Ramachandra,
Nerkar Devdas Punjaji
Publication year - 1988
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1988.tb01387.x
Subject(s) - vibrio parahaemolyticus , stimulation , biology , microbiology and biotechnology , macrophage , lipid a , enzyme , lipid metabolism , toxicity , biochemistry , pharmacology , bacteria , lipopolysaccharide , immunology , in vitro , endocrinology , medicine , genetics
The toxicity and macrophage stimulating property of Vibrio parahaemolyticus lipid A was studied. The LD 50 dose of lipid A in galactosamine‐sensitized mice was found to be 0.6 μ g when injected intraperitoneally. Administration of lipid A resulted in stimulation of peritoneal macrophages as evident by increase in their cellular RNA contents and lysosomal enzyme activities. The treatment also caused enhancement in the phagocytic activity of macrophages.