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Monoclonal Antibodies to O4 Antigen of Vibrio parahaemolyticus
Author(s) -
Ogawa Setsuko,
Koshikawa Tomihiko,
Watabe Kazuhito,
Yamazoe Mari,
Torii Mitsuo,
Sakato Nobuo,
Azuma Takachika,
Fujio Hajime
Publication year - 1988
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1988.tb01379.x
Subject(s) - vibrio parahaemolyticus , monoclonal antibody , antigen , biology , agglutination (biology) , microbiology and biotechnology , antibody , galactose , galactosamine , vibrio , bacteria , latex fixation test , epitope , biochemistry , immunology , genetics
Four monoclonal antibodies were prepared against O4 antigen of Vibrio parahaemolyticus. All the antibodies were shown to be specific for O4 antigen by agglutination with heat‐killed O‐cells of the organism and precipitation with LPS preparations. The inhibition experiments of the precipitations with various sugars and oligosaccharides suggested that the combining sites of these hybridoma antibodies were directed to an antigenic determinant structure containing →3 and →6 linked d‐glucose, d‐galactose, and N ‐acetyl‐d‐galactosamine.