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Induction of Resistance in Mice by the Capsular Polysaccharide Antigens of Staphylococcus aureus
Author(s) -
Yoshida Kosaku,
Umeda Akiko,
Ohshima Yukio
Publication year - 1987
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1987.tb03125.x
Subject(s) - microbiology and biotechnology , polysaccharide , biology , heterologous , bacterial capsule , staphylococcus aureus , antiserum , agar , antigen , homologous chromosome , bacteria , immunology , biochemistry , virulence , genetics , gene
Mice actively immunized with capsular polysaccharides extracted from capsular type strains A, B, C, and D, determined by the serum‐soft agar technique, were protected against lethal infection by homologous strains, but no animals survived infection by heterologous substance immunization even with at high doses. Passive protective antibody in rabbit antisera prepared using these strains was absorbed out only by homologous capsular polysaccharide in mice. These results indicated that resistance was specific for capsular polysaccharide. The substance contained mainly neutral sugar, small amounts of hexosamine, methyl‐pentose, and phosphate although these amounts varied depending on the capsular types strains.