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Temperature‐Modulated Physiological Characteristics of Candida albicans
Author(s) -
Hazen Kevin C.,
Hazen Beth W.
Publication year - 1987
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1987.tb03112.x
Subject(s) - candida albicans , germ tube , virulence , biology , germination , microbiology and biotechnology , corpus albicans , biochemistry , botany , gene
Despite numerous investigations on candidiasis, definitive conclusions concerning virulence factors are few because of oftentimes confusing and contradictory results. By utilizing various physiologic tests, which include germ tube induction, inhibition of germination by a morphogenic autoregulatory substance, enzyme production, susceptibility to exogenous chemicals, and cell surface hydrophobicity, we demonstrated that such variability is due, in part, to the environmental conditions in which cells were grown in preparation for analysis. Room‐temperature grown cells were generally less sensitive to environmental perturbation and germinated more uniformly than cells grown at 37 C. The implication of these results in relation to pathogenic studies and the epidemiology of candidiasis is suggested.