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Association of HLA DR1 with High d‐Penicillamine Binding to Monocytes in Females
Author(s) -
Watanabe Hiroshi,
Kelly Heath,
Dawkins Roger L.
Publication year - 1987
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1987.tb03070.x
Subject(s) - penicillamine , biology , human leukocyte antigen , association (psychology) , immunology , medicine , antigen , philosophy , epistemology
Binding of d‐Penicillamine (d‐Pen) to human monocytes was examined by flow cytometry with fluorescent d‐Pen conjugate. Cells from HLA DR1‐positive healthy females bound significantly more d‐Pen than cells from DR1‐negative healthy females ( P =0.015), and DR1 was associated with the highest binding among HLA DR antigens. In contrast, DR4 was associated with the lowest binding in healthy females. A difference in d‐Pen binding between healthy females who were DR1‐positive, DR4‐negative and those who were DR1‐negative, DR4‐positive was statistically significant ( P =0.026). Neither healthy females nor healthy males showed significant associations of d‐Pen binding with HLA A, B, or C antigens, nor did healthy males show an association between strength of d‐Pen binding and any DR antigens.