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Characterization and Mobilization of Nonconjugative Plasmids Encoding Resistance to Streptomycin and Sulfanilamide
Author(s) -
Araki Yasuhisa,
Inoue Matsuhisa,
Hashimoto Hajime
Publication year - 1987
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1987.tb01342.x
Subject(s) - plasmid , biology , streptomycin , sulfanilamide , enterobacteriaceae , microbiology and biotechnology , escherichia coli , genetics , gene , antibiotics , biochemistry
Most of nonconjugative streptomycin (Sm)‐ and sulfanilamide (Su)‐resistance of clinical isolates belonging to various species of Enterobacteriaceae and Pseudomonas were encoded by an Inc Q plasmid, molecular size of which was 5.5 Md. The SmSu plasmids were efficiently mobilized by Inc P plasmids between E. coli strains. Inc I group and Inc F group plasmids could mobilize the Inc Q plasmids at lower efficiencies. The Inc Q plasmid was also mobilized to various species of Enterobacteriaceae at high frequencies without accompanying the conjugative Inc P plasmid; as a result, most of the SmSu‐resistant transconjugants were nontransferable. The above results may explain the wide distribution of nonconjugative SmSu strains among clinical isolates.