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Microbial Adjuvant and Autoimmunity
Author(s) -
Yokochi Takashi,
Nakashima Izumi,
Kato Nobuo,
Asai Junpei,
Miyadai Toshiaki,
Kimura Yoshinobu
Publication year - 1986
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1986.tb02981.x
Subject(s) - spleen , adjuvant , immune system , immunology , lipopolysaccharide , autoimmunity , autoimmune thyroiditis , immunization , immunity , thyroid , biology , humoral immunity , antibody , thyroiditis , endocrinology
The role of humoral and cellular immune responses in the initiation and maintenance of autoimmune thyroiditis was investigated in mice immunized with syngeneic thyroid extract and Klebsiella O3 lipopolysaccharide (KO3 LPS) as an adjuvant. The transfer of spleen cells from hyperimmunized mice to 400R‐irradiated syngeneic mice produced definite lesions in the thyroid glands, whereas the transfer of immune sera failed to do so. No lesions were induced in normal intact mice by the same transfer of sera and spleen cells from hyperimmunized mice. It was suggested that the induction of thyroiditis by immunization using KO3 LPS adjuvant is primarily due to cell‐mediated immunity and that pretreatment of mice by X‐irradiation is essential for production of the lesions. The role of X‐irradiation in the induction of thyroiditis was discussed.

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