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Antichlamydial Activity of Ofloxacin
Author(s) -
Hirai Katsuya,
Une Tsutomu
Publication year - 1986
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1986.tb02970.x
Subject(s) - ofloxacin , chlamydia , chlamydia trachomatis , minocycline , doxycycline , biology , microbiology and biotechnology , chlamydiaceae , chlamydiales , azithromycin , antibiotics , virology , immunology , ciprofloxacin
The in vitro activity of ofloxacin, a new pyridone‐carboxylic acid, against 11 strains of Chlamydia trachomatis and six strains of Chlamydia psittaci was determined. All test strains of both species were inhibited by 0.39 μg of ofloxacin per ml. The antichlamydial activity of ofloxacin was comparable to that of doxycycline and four‐ to eightfold less than that of minocycline. The results of this susceptibility test, coupled with those of previous pharmacokinetic analyses of ofloxacin, warrant further evaluation of its clinical usefulness against chlamydial infections.