Premium
Induction of Antibodies against Newcastle Disease Virus with Syngeneic Anti‐Idiotype Antibodies in Mice
Author(s) -
Tanaka Masayuki,
Sasaki Norimasa,
Seto Akira
Publication year - 1986
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1986.tb00949.x
Subject(s) - idiotype , newcastle disease , virology , antibody , hemagglutinin (influenza) , biology , virus , immunology , monoclonal antibody
Anti‐idiotype antibodies were induced by injecting BALB/c mice with syngeneic antibody against the hemagglutinin of Newcastle disease virus (NDV). These anti‐idiotype antibodies were purified and injected into syngeneic mice. Anti‐anti‐idiotype sera thus prepared contained antibodies against the hemagglutinin of NDV. This NDV‐mouse experimental system might provide a good experimental model for investigation of basic problems of idiotype vaccine.