Premium
Immunogenicity and Protective Effect of Hemolysis Mutants of Mycoplasma pneumoniae
Author(s) -
Yayoshi Masumi,
Araake Minako,
Hayatsu Eizo,
Takezawa Toshiyuki,
Yoshioka Morimasa
Publication year - 1985
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1985.tb00893.x
Subject(s) - immunogenicity , mycoplasma pneumoniae , biology , vaccination , immune system , virulence , microbiology and biotechnology , hemolysis , strain (injury) , virology , mycoplasma , attenuated vaccine , immunology , gene , medicine , pneumonia , genetics , anatomy
Two attenuated strains of Mycoplasma pneumoniae , P24‐S1 and P24‐S11, were tested for their ability as a live vaccine to confer on hamsters immune resistance against challenge infection with a virulent strain of M. pneumoniae , FH‐P24. Fifty percent protection was obtained by vaccination with the P24‐S1 strain administered once or twice. In contrast, only 10% of the animals were protected by the P24‐S11 vaccine even when it was given three times. Vaccination with the P24‐S1 strain resulted in higher humoral and cellular immune responses than the P24‐S11 did. These results suggest that the P24‐S1 strain has the primary qualities a vaccine which may be used for protection against human mycoplasmal infection.