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Development of DTH Skin Reaction to HBsAg in Individuals Immunized with HB Vaccine
Author(s) -
Kashiwagi Seizaburo,
Nagafuchi Seiho,
Inoue Takatoshi,
Hayashi Shin,
Takeshita Shigemori,
Imayama Shuhei
Publication year - 1984
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1984.tb00793.x
Subject(s) - hbsag , immunology , skin reaction , vaccination , antibody response , antibody , virology , biology , medicine , virus , hepatitis b virus
To examine the temporal relationship between the DTH skin reaction to HBsAg and antibody response to HBsAg, serial skin tests for HBsAg were carried out on seven individuals immunized with HB vaccine. All cases developed both a skin reaction and antibody response. In many cases, the DTH skin reaction appeared four weeks before the antibody response. These data suggest that DTH skin reaction may be a more sensitive method than humoral antibody assessment for monitoring the success of vaccination.