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Cells Participating in Immunologic Memory Induced with RNA from the Spleens of Immunized Mice
Author(s) -
Kodama Kazue,
Yoshida Toshiharu,
Kurashige Satonori,
Mitsuhashi Susumu
Publication year - 1984
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1984.tb00713.x
Subject(s) - rna , biology , heterologous , immune system , antigen , b 1 cell , spleen , microbiology and biotechnology , immunology , antigen presenting cell , t cell , gene , genetics
Ribonucleic acid (immune RNA, i RNA) extracted from the spleens of mice immunized with heterologous red blood cells induced antigen‐specific immunologic memory. The type of cells (T cells, B cells) which participate in immunologic memory induced with i RNA was investigated. Immune RNA‐primed T cells cooperated with normal, i RNA‐primed or antigen‐primed B cells and induced a high IgM response. Immune RNA‐primed B cells did not cooperate with normal T cells, but did with i RNA‐ or antigen‐primed T cells. The activities of i RNA‐primed T and B cells were antigen‐specific.