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“Original Antigenic Sin” Phenomenon in Experimental Flavivirus Infections of Guinea Pigs: Studies by Enzyme‐Linked Immunosorbent Assay
Author(s) -
Inouye Sakae,
Matsuno Shigeo,
Tsurukubo Yoshito
Publication year - 1984
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1984.tb00709.x
Subject(s) - virology , biology , flavivirus , antibody , antigen , virus , hemagglutination , antibody response , immunology
Abstract Guinea pigs were sequentially infected with two closely related flavivituses (Japanese encephalitis and West Nile viruses), and their antibody responses were studied both by enzyme‐linked immunosorbent assay (ELISA) and hemagglutination‐inhibition (HI). The results by ELISA always showed “original antigenic sin” responses: antibody activity of sera after the second infection was higher to the first infecting virus than to the second infecting virus. However, the results obtained by HI were variable.