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Antibody‐Dependent Cellular Cytotoxicity and Natural Killer Cytotoxicity of Peritoneal Cells from Nude Mice to Herpes Simplex Virus‐Infected Cells
Author(s) -
Kohl Steve,
Tang JyPing,
Loo Lian Sim
Publication year - 1984
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1984.tb00695.x
Subject(s) - antibody dependent cell mediated cytotoxicity , cytotoxicity , biology , herpes simplex virus , antibody , immune system , virology , immunology , natural killer cell , virus , microbiology and biotechnology , monoclonal antibody , in vitro , biochemistry
Nude BALB/ c mice (athymic) were more susceptible to fatal herpes simplex virus (HSV) than normal BALB/ c mice ( P =0.002). The peritoneal cells of nude mice mediated levels of antibody‐dependent cellular cytotoxicity (ADCC) of equal or greater magnitude than cells from normal BALB/ c , heterozygote nu/+, or C57BL/6 mice. Unstimulated natural killer cytotoxicity of peritoneal cells from nude mice was higher ( P <0.05) than that mediated by cells from C57BL/6 mice. Nude mice failed to make anti‐HSV ADCC antibody 6 to 14 days post HSV inoculation, at times when nu/+, BALB/ c , and C57BL/6 mice produced antibody. Passive reconstitution of nude mice with high titer intraperitoneal anti‐HSV immune globulin provided circulating anti‐HSV ADCC antibody and significant protection against lethal HSV infection.