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Antigenic and Biochemical Characterization of Poliovirus Type 1 Isolates of Non‐Vaccine Origin
Author(s) -
Hara Minora,
Hagiwara Akio,
Yoneyama Tetsuo,
Saito Yoshiko,
Shimojo Hiroto
Publication year - 1983
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1983.tb02939.x
Subject(s) - antigenicity , virology , poliovirus , biology , virulence , microbiology and biotechnology , strain (injury) , antigen , virus , gene , genetics , anatomy
During the past 15 years, five poliovirus type 1 strains with non‐vaccinelike antigenicity have been isolated in Japan. Of these isolates, two were from paralytic poliomyelitis patients not associated with the use of Sabin vaccine, and three were apparently introduced from abroad. All the isolates could be readily distinguished from the corresponding Sabin type 1 vaccine strain by oligonucleotide mapping of the viral RNA and by polyacrylamide gel electrophoresis of the viral proteins. The oligonucleotide map of the virulent Mahoney strain which has non‐vaccine‐like antigenicity was very similar to the map of Sabin type 1 strain. These data indicate that none of the isolates were derived from Sabin type 1 vaccine or its parental Mahoney strain. In addition, some isolates had close antigenic relationship with one another. It is probable that all these strains were introduced from foreign lands where wild poliovirus strains are prevalent.