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Dose‐Dependent Induction of Immunologic Enhancement and Suppression after Oral Administration of Antigen
Author(s) -
Yasui Hisako,
Ohwaki Makoto
Publication year - 1983
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1983.tb02931.x
Subject(s) - antigen , biology , immunology , oral administration , pharmacology
Abstract The effects of feeding various quantities of a particulate antigen, sheep red blood cells (SRBC), on plaque‐forming cells (PFC) in the spleen were determined. Mice were given various numbers of SRBC orally daily for 14 days, then injected with SRBC intravenously. Splenic IgA PFC responses to SRBC were enhanced in the mice fed 5 × 10 8 SRBC and splenic IgG PFC responses to SRBC were depressed in the mice fed 5 × 10 9 SRBC. Adoptive transfer experiments showed that enhancement of splenic IgA PFC responses and suppression of splenic IgG PFC responses were induced by the T‐cell rich fraction from Peyer's patches (PP) and the spleen in 5 × 10 8 SRBC‐ and 5 × 10 9 SRBC‐fed mice, respectively. Kinetic studies revealed that IgA helper cells or IgG suppressor cells appeared in PP 2 days after oral administration and 4 days after it in the spleen.