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Suppression of Cell Mediated Immunity to Cytomegalovirus and Tuberculin in Pregnancy Employing the Leukocyte Migration Inhibition Test
Author(s) -
Tanaka Akira,
Hirota Kiyokata,
Takahashi Katsuyuki,
Numazaki Yoshio
Publication year - 1983
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1983.tb00659.x
Subject(s) - immunity , pregnancy , cytomegalovirus , cell mediated immunity , immunology , cellular immunity , biology , gestation , tuberculin , immune system , medicine , herpesviridae , viral disease , tuberculosis , virus , pathology , genetics
To clarify the mechanism of reactivation of cytomegalovirus (CMV) in pregnancy, cell mediated immunity to CMV was investigated in 108 pregnant and 29 postpartal women employing the leukocyte migration inhibition technique. It was demonstrated that CMV‐specific cell mediated immunity was suppressed as gestation progressed in 20% of the seropositive women during the first trimester, in 78% during the second trimester and in all at term. The suppression of cell mediated immunity during pregnancy ceased 8 weeks after parturition. The results suggested that reactivation of CMV in pregnancy was probably caused by the suppression of CMV‐specific cell mediated immunity.