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Antiviral and Antiproliferative Activities of Three Molecular Components of Leukocyte‐Derived Human Interferon
Author(s) -
Dinolfo Elaine,
Chadha Kailash C.
Publication year - 1983
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1983.tb00620.x
Subject(s) - biology , interferon , virology , alpha interferon , immunology , computational biology
Antiviral and antiproliferative activities of three naturally occurring components of leukocyte‐derived human interferon (HuIFN‐α) separated by concanavalin A‐agarose affinity chromatography were studied in a variety of neoplastic cell lines. Significant differences were seen with these different components. The results strongly suggest that careful consideration must be given while selecting any one component of HuIFN‐α for any of the antiviral or antiproliferative studies. There is no clear evidence that glycosylation of HuIFN‐α has any significant influence on its in vitro antiviral or antiproliferative activities, although apparently glycosylated and non‐glycosylated components gave different antiviral and antiproliferative responses in different tumor cells.