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Immune Response to Toxoplasma gondii
Author(s) -
Yano Akihiko,
Yui Katsuyuki,
Yamamoto Masuji,
Aosai Fumie,
Furuta Seiichi,
Kojima Soumei
Publication year - 1983
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1983.tb00604.x
Subject(s) - toxoplasma gondii , toxoplasmosis , biology , immunology , monoclonal antibody , immune system , in vitro , inducer , thymidine , antibody , virology , biochemistry , gene
Peripheral blood leukocytes (PBL) from patients with toxoplasmosis were shown to be highly responsive to in vitro stimulation with Toxoplasma gondii extract as measured by incorporation of [ 3 H]methylated thymidine. Analysis of Toxoplasma ‐specific proliferative cells in PBL by using monoclonal antibodies specific for human T cell subsets revealed that the Toxoplasma ‐specific proliferation response of PBL from the patients was mediated by Leu 1, Leu 3a positive cells, that is, helper/inducer T cells. Tests for the Toxoplasma ‐specific proliferation response may provide a readily available method for the diagnosis of congenital toxoplasmosis, especially during the newborn period.