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Effect of Immune Heterozygous Spleen Cell Transfer on Resistance to Mouse Hepatitis Virus Infection in Nude Mice
Author(s) -
Kai Chieko,
Tamura Teruko,
Fujiwara Kôsaku
Publication year - 1981
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1981.tb00107.x
Subject(s) - biology , spleen , virology , immune system , virus , immunology , mouse hepatitis virus , hepatitis a virus , infectious disease (medical specialty) , medicine , pathology , disease , covid-19
The role of cell mediated immune response to mouse hepatitis virus (MHV) infection in mice was studied by transferring spleen cells from immune heterozygous littermates (nu/+). A suppressive effect on viral growth was seen in infected nude (nu/nu) mice, whereas immune nu/+ serum transfer had no effect. The protective effect of immune nu/+ spleen cells was significantly reduced by treatment with anti‐theta serum plus complement but not with anti‐Ig serum. In infected nu/nu mice which received transfers of immune nu/+ cells, neutralizing antibody appeared although the titer was not high enough to protect nu/nu mice from fatal infection. Histopathologically, lymphocyte infiltration in hepatic lesions was evident in infected nu/nu mice with nu/+ cell transfer, while it was slight without nu/+ cell transfer.