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Inhibitory Effect of 1‐β‐D‐Arabinofuranosylthymine on Synthesis of Epstein‐Barr Virus
Author(s) -
Yonemura Kensuke,
Sairenji Takeshi,
Hinuma Yorio
Publication year - 1981
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1981.tb00057.x
Subject(s) - biology , epstein–barr virus , virus , antigen , cell culture , microbiology and biotechnology , virology , lymphoblast , capsid , strain (injury) , viral replication , inhibitory postsynaptic potential , immunology , genetics , anatomy , neuroscience
The effect of 1‐ β ‐d‐arabinofuranosylthymine (ara‐T) on cell growth and synthesis of Epstein‐Barr virus (EBV) in human lymphoblastoid cell lines was determined. The growth of P3HR‐1 cells was not inhibited by 1 μ g of the drug per ml; however, infectious virus production was strongly inhibited and was accompanied by decreased expression of early antigen (EA) and viral capsid antigen (VCA). The ability of 12‐ O ‐tetradecanoylphorbol‐13‐acetate or n ‐butyric acid to induce synthesis of VCA, but not EA, in P3HR‐1 cells was inhibited by ara‐T. Similarly, VCA synthesis but not EA synthesis was inhibited by ara‐T in Jijoye cells superinfected with the P3HR‐1 strain of EBV. The results suggest that ara‐T has a specific inhibitory action against EBV replication.