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Immunopotentiating Activity of Whole Cells and Mini‐Cells of Salmonella typhimurium
Author(s) -
Kurashige Satonori,
Yoshida Toshiharu,
Kodama Kazue,
Mitsuhashi Susumu
Publication year - 1981
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1981.tb00049.x
Subject(s) - biology , cytotoxic t cell , immune system , microbiology and biotechnology , l1210 cells , phagocytosis , salmonella , in vitro , b 1 cell , cd40 , cancer cell , interleukin 12 , immunology , cytotoxicity , bacteria , cancer , biochemistry , genetics
Salmonella typhimurium strain 9 produces mini‐cells during cell proliferation. Mini‐cells are viable but cannot proliferate since they do not contain chromosomal DNA. Effects of whole cells and mini‐cells of S. typhimurium on the immune responses were investigated, with the following results. Phagocytosis of peritoneal macrophages was enhanced by in vivo stimulation of both whole cells and mini‐cells. Cellular immunity against L1210 cells (mouse leukemia cells) and Sarcoma 180 cells was also enhanced by both whole cells and mini‐cells. Mini‐cells slightly stimulated in vitro blast cell transformation of normal mouse lymphocytes. Whole cells of S. typhimurium induced antibody‐forming cells to produce IgG of higher affinity but mini‐cells did not. Mini‐cells were not directly cytotoxic for normal lymphocytes or L1210 cells.