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Biological Properties of Plaque‐Size Variants of Sendai Virus
Author(s) -
Sugita Kenji,
Maru Morimasa,
Sato Kosaburo
Publication year - 1981
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1981.tb00037.x
Subject(s) - sendai virus , trypsin , biology , virus , virulence , microbiology and biotechnology , virology , enzyme , biochemistry , gene
Large (RL)‐ and small (RS)‐plaque variants of Sendai virus were isolated in cultures of LLCMK2 cells in the presence of trypsin and their biological properties were determined. The RL variant was more virulent to mice than the RS variant. The RL variant had a higher growth rate than the RS variant in multiple‐step growth in the presence of trypsin, but the two variants had an almost equal growth rate in its absence. Restoration of hemolytic activity and cleavage of the F protein of the RL variant were achieved by milder trypsin treatment than was needed for the RS variant.