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Complement Proteins and Macrophages
Author(s) -
Miyama Akio,
Kawamoto Yasuko,
Ighikawa Hidetaka,
Moriyama Takeshi,
Okamoto Keinosuke,
Takahashi Tetsuomi
Publication year - 1981
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1981.tb00022.x
Subject(s) - zymosan , complement factor b , biology , secretion , ingestion , acid phosphatase , alternative complement pathway , macrophage , complement factor i , enzyme , biochemistry , immunology , endocrinology , medicine , complement system , immune system , in vitro
A kinetic study of factor B secretion by particle‐ingesting macrophages showed that the ingestion of zymosan but not latex lead to an early suppression of factor B secretion followed by a significant enhancement. This dual response was proportional to the number of ingested zymosans. After a suppressive period of 24–48 hr, the ingested zymosan stimulated the synthesis of factor B. The response of acid phosphatase synthesis to ingested zymosan was the same as that of factor B, while the synthesis of lactic dehydrogenase proceeded without an early suppression. These results suggest that factor B should be considered an enzyme released into the lysosomes of macrophages.